منابع مشابه
Hypertrophy of the Heart
Recent studies call into question the necessity of hypertrophic growth of the heart as a “compensatory” response to hemodynamic stress. These findings, coupled with recent progress in dissecting the molecular bases of hypertrophy, raise the prospect of suppressing hypertrophy without provoking circulatory insufficiency. In this article, we focus on signaling pathways that hold promise as potent...
متن کاملHypertension, hypertrophy, heart failure.
Heart failure presents a number of difficulties. Its very definition has proved taxing, and the clinical diagnosis is frequently incorrect. Patients with objective abnormalities of left ventricular function are not infrequently asymptomatic, hence treatment is often delayed. Even when a firm diagnosis is secured, only a minority of patients receive optimal medical treatment. Of concern is the i...
متن کاملCalcineurin in human heart hypertrophy.
BACKGROUND In animal models, increased signaling through the calcineurin pathway has been shown to be sufficient for the development of cardiac hypertrophy. Calcineurin activity has been reported to be elevated in the myocardium of patients with congestive heart failure. In contrast, few data are available about calcineurin activity in patients with pressure overload or cardiomyopathic hypertro...
متن کاملCardiac Hypertrophy and Heart Failure
In cardiac and skeletal muscle, the sarcoplasmic reticulum (SR) plays a central role in the contraction relaxation cycle of the muscle by virtue of its ability to regulate the intracellular free Ca'+ concentration [Ca'+],. Ca'+ release from the SR increases [Ca'+] (10`mol/L), thus inducing contraction, whereas Ca2` uptake by the SR reduces [Ca'+] (=10-7 mol/L), producing muscle relaxation. In c...
متن کاملTonin in rat heart with experimental hypertrophy.
The present study was undertaken to determine tonin expression and activity in rat heart presenting isoproterenol-induced hypertrophy. Renin, angiotensin-converting enzyme (ACE), and angiotensinogen (AG) expression were also determined. Wistar rats were treated with isoproterenol for 7 days (5 mg x kg(-1) x day(-1) sc). For untreated animals, the levels of tonin-specific activity in the atrium ...
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ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2011
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2010.12.012